Why the study?
Does prostaglandin infusion or inhibition alter the arrhythmogenic dose of epinephrine in halothane-anesthetized dogs?
Does prostaglandin infusion or inhibition alter the arrhythmogenic dose of epinephrine in halothane-anesthetized dogs?
Inhibition of prostaglandin synthesis with indomethacin does not increase the likelihood of epinephrine-induced ventricular arrhythmias during halothane anesthesia in a canine model.
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Indomethacin does not alter epinephrine arrhythmogenicity in this canine model; leaves open prostaglandin relevance to human halothane anesthesia.
Pace et al. (1979) studied this question.
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