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July 1, 1985Journal of Cardiovascular Pharmacology

Inhibition by Prostaglandins of Adrenergic Transmission in the Left Ventricular Myocardium of Anesthetized Dogs

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Why the study?

Do prostaglandins alter cardiac adrenergic transmission in the left ventricle of anesthetized dogs?

Population

Pentobarbital-anesthetized dogs (intact left ventricle)

Comparison

Prostaglandin synthesis inhibition and… vs Baseline (before inhibition or infusion)

Design

Preclinical

Authors

SLStephen M. LanierWayne State UniversityKMKafait U. MalikUniversity of Tennessee Health Science Center

Discussion

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Implication

Should not change clinical management of ventricular sympathetic activity; leaves open relevance of prostaglandin pathways in human heart disease models.

Structured PICO

Do prostaglandins alter cardiac adrenergic transmission in the left ventricle of anesthetized dogs?

P
Population
Pentobarbital-anesthetized dogs (intact left ventricle)
I
Intervention
Prostaglandin synthesis inhibition (indomethacin 10 mg/kg i.v.) and intracoronary infusion of PGE2 (30 ng kg-1 min-1) and PGI2 (60 ng kg-1 min-1)
C
Comparator
Baseline (before inhibition or infusion)
O
Outcome
Positive inotropic response (dP/dtmax) and coronary sinus output of norepinephrine (NE) elicited by left cardiac sympathetic nerve stimulation and intracoronary injections of NEsurrogate

Prostaglandins synthesized in the heart inhibit cardiac adrenergic transmission in the left ventricle in vivo by reducing norepinephrine release and attenuating its action at effector cells.

Cite This Study

Lanier et al. (1985) studied this question.

synapsesocial.com/papers/6a87c33fba4ee383afbb538ehttps://doi.org/10.1097/00005344-198507000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prostaglandin E1 increases myocardial contractility in the conscious dog1984 · 11 citations
  2. 2Prostacyclin (PGI2) lowers heart rate in the conscious dog1981 · 20 citations
  3. 3PGE2 and arachidonate inhibit the baroreflex in conscious dogs via cardiac receptors1989 · 28 citations
  4. 4Different effects of prostaglandins on adrenergic neurotransmission in atrial and ventricular preparations1990 · 9 citations
  5. 5Prostaglandin E1 and Nitroglycerin Effects on Canine Epicardial Conductance and Distal Coronary Resistance Vessels1989 · 3 citations