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April 1, 1989AJP Heart and Circulatory Physiology

PGE2 and arachidonate inhibit the baroreflex in conscious dogs via cardiac receptors

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Why the study?

Does intracoronary infusion of PGE2 and arachidonic acid inhibit the baroreflex control of heart rate in conscious dogs?

Population

Conscious dogs instrumented using sterile surgical techniques

Comparison

Intracoronary infusion of PGE2 and arachidonic… vs Intravenous infusion of PGE2; pericoronary nerve…

Design

Preclinical

Authors

MPM. J. PanzenbeckBoehringer Ingelheim (United States)WTWen TanAffiliated Hospital of Southwest Medical UniversityMHM. A. HajduUniversity of Missouri–Kansas City

Discussion

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Implication

PGE2 blunts baroreflex gain via cardiac afferents in dogs; leaves open relevance to human autonomic regulation or therapies.

Structured PICO

Does intracoronary infusion of PGE2 and arachidonic acid inhibit the baroreflex control of heart rate in conscious dogs?

P
Population
Conscious dogs instrumented using sterile surgical techniques
I
Intervention
Intracoronary infusion of PGE2 (10-50 ng.kg-1.min-1) and arachidonic acid (50-100 micrograms.kg-1.min-1)
C
Comparator
Intravenous infusion of PGE2; pericoronary nerve block; cyclooxygenase blockade
O
Outcome
Baroreflex control of heart rate (maximum heart rate, heart rate range, and maximum slope of the baroreflex curve)surrogate

Intracoronary PGE2 and arachidonic acid inhibit baroreflex control of heart rate, likely via stimulation of left ventricular receptors with vagal C-fiber afferents.

Cite This Study

Panzenbeck et al. (1989) studied this question.

synapsesocial.com/papers/6a7b7ebf756812e3958a0793https://doi.org/10.1152/ajpheart.1989.256.4.h999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.1988 · 21 citations
  2. 2Prostacyclin (PGI2) lowers heart rate in the conscious dog1981 · 20 citations
  3. 3INTRACORONARY PGE2 AND VERATRINE INHIBITS RENIN RELEASE IN CONSCIOUS DOGS VIA CHEMOSENSITIVE VENTRICULAR AFFERENTS1992 · 2 citations
  4. 4Inhibition by Prostaglandins of Adrenergic Transmission in the Left Ventricular Myocardium of Anesthetized Dogs1985 · 17 citations
  5. 5PGI2 attenuates baroreflex control of renal nerve activity by a vagal mechanism1988 · 24 citations