February 1, 1986Experimental Biology and Medicine
Prostaglandins Modulate Baroreflex-Induced Changes in Blood Pressure and Myocardial Function in Anesthetized Dogs
Why the study?
Does prostaglandin synthesis blockade alter baroreflex-induced changes in blood pressure and myocardial function in anesthetized dogs?
Population
Anesthetized dogs (N=17)
Comparison
Blockade of prostaglandin synthesis with… vs Bilateral carotid artery occlusion before…
Design
Preclinical
Authors
Discussion
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Implication
Animal data on prostaglandin modulation of baroreflex responses should not change practice; leaves open relevance to human cardiovascular regulation.
Structured PICO
Does prostaglandin synthesis blockade alter baroreflex-induced changes in blood pressure and myocardial function in anesthetized dogs?
P
Population
Anesthetized dogs (N=17)
I
Intervention
Blockade of prostaglandin synthesis with indomethacin (N=11) or meclofenamate (N=6) during bilateral carotid artery occlusion (BCO)
C
Comparator
Bilateral carotid artery occlusion (BCO) before inhibition of prostaglandin synthesis
O
Outcome
Changes in arterial pressures (systolic, diastolic, mean) and myocardial function (LV systolic pressure, LV dP/dt, cardiac work)surrogate
Systemic prostaglandin synthesis modulates baroreflex-induced increases in systemic arterial pressure and myocardial function without affecting coronary blood flow regulation.
Cite This Study
Hintze et al. (1986) studied this question.