Key result
In anaesthetized, vagotomized dogs, bilateral carotid occlusion induces vasodilatation of the large coronary artery (0.14 ± 0.04 mm), which is reversed to vasoconstriction by beta-blockade.
Why the study?
Does carotid sinus reflex stimulation alter large coronary artery diameter and coronary resistance in anaesthetized dogs?
Population
Anaesthetized dogs
Comparison
Stimulation of the carotid sinus reflex by… vs Baseline measurements prior to occlusion
Design
Preclinical
Follow-up
2 minutes (duration of occlusion)
Authors
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Beta-blockade may unmask coronary vasoconstriction during carotid activation; leaves open translation to human physiology and practice.
Does carotid sinus reflex stimulation alter large coronary artery diameter and coronary resistance in anaesthetized dogs?
The tone of large coronary arteries and coronary resistance vessels is regulated by neural reflexes, with alpha-adrenergic vasoconstriction unmasked by beta-blockade during carotid sinus reflex stimulation.
Owen L. Woodman (1987) studied this question. Bilateral occlusion of the carotid arteries (BCO) vs. Baseline / pharmacological blockades was evaluated on Coronary artery diameter and late diastolic coronary resistance. In anaesthetized, vagotomized dogs, bilateral carotid occlusion induces vasodilatation of the large coronary artery (0.14 ± 0.04 mm), which is reversed to vasoconstriction by beta-blockade.
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