Population
Rabbits anesthetized with chloralose, with vascularly isolated carotid sinus.
Comparison
Exposure of isolated carotid sinus to… vs Control measurements (baseline).
Design
Preclinical
Authors
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Hypothesis-generating for PGI2 modulation of baroreflex sensitivity in animals; human studies needed before clinical translation.
Prostaglandins, such as PGI2, released from the endothelium appear to contribute in a paracrine manner to the activation of baroreceptors during increases in arterial pressure.
Chen et al. (1990) studied this question.
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