Population
Rabbits anesthetized with pentothal and chloralose, divided into chronic renal hypertensive and normotensive…
Comparison
Intrasinus administration of indomethacin… vs Normotensive rabbits and baseline measurements…
Design
Preclinical
Authors
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Supports reduced prostacyclin as driver of baroreceptor impairment in hypertension; leaves open human translation and therapeutic relevance.
Decreased baroreceptor activity in chronic hypertension may be driven by reduced endogenous prostacyclin formation rather than decreased sensitivity or vascular distensibility.
Xie et al. (1990) studied this question.
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