January 1, 1991HypertensionOpen Access

Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pressure.

View Full Paper

Ask AI

Bookmark

Population

Hypertensive and normotensive rabbits anesthetized with chloralose

Comparison

Acute changes in arterial pressure vs Normotensive rabbits and baseline control…

Design

Preclinical

Authors

PXP L XieQinghai University Affiliated Hospital TMT. McDowellUniversity of Iowa MCMark W. ChapleauGeneral Cardiology

Discussion

Member takes

Implication

Does not change clinical practice; leaves open baroreceptor resetting as a hypertension mechanism or target in humans.

Structured PICO

Population

Hypertensive (one-kidney, one wrap) and normotensive (one-kidney, no wrap) rabbits anesthetized with chloralose

Intervention

Acute changes in arterial pressure (holding pressure increased or decreased by 30 and 60 mm Hg for 10-15 minutes)

Comparator

Normotensive rabbits and baseline control measurements

Outcome

Baroreceptor threshold pressure (Pth) and extent of baroreceptor resettingsurrogate

In a rabbit model, chronic hypertension impairs the ability of baroreceptors to rapidly reset to increased pressure, but acute normalization of blood pressure can restore normal baroreceptor threshold and nerve activity.

Cite This Study

Xie et al. (1991) studied this question.

synapsesocial.com/papers/6a82d05b8aa2f088808d67cc https://doi.org/10.1161/01.hyp.17.1.72

View Full Paper

Ask AI

Bookmark

Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pressure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pressure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider