Why the study?
Does chronic renal hypertension alter the impulse activity and sensitivity of single baroreceptor fibers in rabbits?
Population
Rabbits with experimental chronic renal hypertension induced by wrapping polyethylene around one kidney and…
Comparison
Induction of chronic renal hypertension vs Normal rabbits
Design
Preclinical
Follow-up
7-19 weeks postoperatively
Authors
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May explain sustained hypertension via baroreceptor resetting in models; leaves open human translation.
Does chronic renal hypertension alter the impulse activity and sensitivity of single baroreceptor fibers in rabbits?
Chronic renal hypertension in rabbits leads to increased threshold pressure and reduced sensitivity of aortic and right subclavian baroreceptors, which is associated with mechanical and histological changes in the arterial walls.
Jennifer E. Angell‐James (1973) studied this question.
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