Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1974Circulation Research

Arterial Baroreceptor Activity in Rabbits with Experimental Atherosclerosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does experimental atherosclerosis alter arterial baroreceptor activity in rabbits?

Population

33 rabbits

Comparison

Experimental atherosclerosis induced by lipemic… vs Normal rabbits on standard diet

Design

Preclinical

Follow-up

up to 67 weeks

Authors

JAJENNIFER E. ANGELL-JAMESSt Bartholomew's Hospital

Discussion

Loading...

Member takes

Implication

Impaired baroreceptor sensitivity in atherosclerotic rabbits may contribute to hypertension; leaves open translation to human disease mechanisms.

Key Points

  • This research aims to understand how atherosclerosis affects arterial baroreceptor activity and associated blood pressure changes in rabbits.
  • 16 rabbits were fed a diet to induce atherosclerosis over 67 weeks.
  • Baroreceptor fibers were isolated, and impulse activity was measured under varying perfusion pressures.
  • Pressure thresholds and response gradients were compared between atherosclerotic and normal rabbits.
  • Mean blood pressure increased from 85 to 114 mm Hg in atherosclerotic rabbits.
  • Baroreceptor impulse frequency decreased significantly (P < 0.02) in atherosclerotic rabbits compared to normal.
  • Correlation coefficient (r = 0.96) indicated a strong linkage between reduced baroreceptor sensitivity and diet duration.

Structured PICO

Does experimental atherosclerosis alter arterial baroreceptor activity in rabbits?

P
Population
33 rabbits (16 with experimental atherosclerosis induced by a diet containing 1% cholesterol and 6% sunflower seed oil for up to 67 weeks, and 17 normal rabbits)
I
Intervention
Experimental atherosclerosis induced by lipemic diet
C
Comparator
Normal rabbits on standard diet
O
Outcome
Impulse activity of single aortic and right subclavian baroreceptor fibers during step increases and decreases in perfusion pressuresurrogate

Experimental atherosclerosis in rabbits reduces the sensitivity of aortic baroreceptors, which may partly account for mild hypertension and suggest similar mechanisms in humans.

Cite This Study

JENNIFER E. ANGELL-JAMES (1974) studied this question.

synapsesocial.com/papers/6a79669ee357fbdac5890410https://doi.org/10.1161/01.res.34.1.27
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Static Load‐Length Characteristics of Aortic Strips from Hypertensive Rabbits1968 · 38 citations
  2. 2The responses of aortic arch and right subclavian baroreceptors to changes of non‐pulsatile pressure and their modification by hypothermia1971 · 60 citations
  3. 3THE INFLUENCE OF MECHANICAL FACTORS ON THE STRUCTURE OF THE PERIPHERAL ARTERIES AND THE LOCALIZATION OF ATHEROSCLEROSIS1960 · 33 citations
  4. 4Dependence of Wall Stress in the Human Thoracic Aorta on Age and Pressure1967 · 190 citations
  5. 5Localization and Sequence of Development of Atherosclerotic Lesions in the Carotid and Vertebral Arteries1971 · 205 citations