Why the study?
Do oxygen-derived free radicals contribute to baroreceptor dysfunction in atherosclerotic rabbits?
Population
28 anesthetized rabbits, including 15 atherosclerotic rabbits and 13 normal rabbits.
Comparison
Exposure of the isolated carotid sinus to… vs Normal rabbits and baseline baroreceptor activity.
Design
Preclinical
Authors
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Hypothesis-generating for oxidative stress in atherosclerotic baroreceptor dysfunction; clinical translation requires prospective validation.
Do oxygen-derived free radicals contribute to baroreceptor dysfunction in atherosclerotic rabbits?
Endogenous oxygen-derived free radicals produced in atherosclerotic carotid sinuses contribute to baroreceptor dysfunction, which can be partially reversed by free-radical scavengers.
Li et al. (1996) studied this question.
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