February 1, 1993Proceedings of the National Academy of SciencesOpen Access

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

View Full Paper

Ask AI

Bookmark

Population

Normal and tumor cells (nonexcitatory cells)

Comparison

Gamma-irradiation, hydrogen peroxide… vs Untreated cells, or cells pretreated with…

Design

Preclinical

Authors

SKS. S. KuoNeurological Surgery ASA.H. SaadStanford University AKAlbert C. KoongThe University of Texas MD Anderson Cancer Center

Discussion

Member takes

Implication

K+ channel activation marks early oxidative stress response; leaves open its impact on radiation sensitivity in vivo.

Structured PICO

Population

Normal and tumor cells (nonexcitatory cells)

Intervention

Gamma-irradiation, hydrogen peroxide, xanthine/xanthine oxidase, or [3H]thymidine

Comparator

Untreated cells, or cells pretreated with N-acetyl-L-cysteine (NAC)

Outcome

Potassium (K+) channel activity measured by whole-cell voltage clampingsurrogate

An early cellular response to oxidative stress and gamma-irradiation involves the activation of K+ channels at the cell membrane, independent of protein kinase C.

Cite This Study

Kuo et al. (1993) studied this question.

synapsesocial.com/papers/6a7209f7439bab0cabc3be1c https://doi.org/10.1073/pnas.90.3.908

View Full Paper

Ask AI

Bookmark

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider