Key result
Expression and activation of voltage-dependent potassium channels correlated with heat resistance in mammalian fibrosarcoma cells, suggesting channel activation is an early event in the heat shock response.
Activation of voltage-dependent K+ channels correlates with heat resistance and may be an early event in initiating the cellular heat shock response.
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Should not alter hyperthermia protocols; hypothesis-generating for K+ channel targeting in heat shock response.
Saad et al. (1992) studied Heat shock response. Heat exposure and Tetraethylammonium (TEA) / DMSO vs. Unheated cells / RIF-1 cells without TEA/DMSO was evaluated on Induction of voltage-dependent potassium currents and heat resistance. Expression and activation of voltage-dependent potassium channels correlated with heat resistance in mammalian fibrosarcoma cells, suggesting channel activation is an early event in the heat shock response.
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