Structural and biomechanical alterations in rabbit thoracic aortas are associated with the progression of atherosclerosis
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Why the study?
Does an atherogenic diet alter aortic wall stiffness and histological structure in male New Zealand White rabbits?
Population
16 male New Zealand White rabbits, weighing 3-3.5 kg.
Comparison
Atherogenic diet for 8 weeks. vs Regular rabbit chow for 8 weeks.
Design
Preclinical, randomly divided into two treatment groups
Follow-up
8 weeks
Authors
Discussion
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Implication
May reduce aortic stiffness in early atherosclerosis models; hypothesis-generating and should not change practice.
Structured PICO
Does an atherogenic diet alter aortic wall stiffness and histological structure in male New Zealand White rabbits?
P
Population
16 male New Zealand White rabbits, weighing 3-3.5 kg.
I
Intervention
Atherogenic diet (4% cholesterol plus regular rabbit chow) for 8 weeks.
C
Comparator
Regular rabbit chow for 8 weeks.
O
Outcome
Mean vessel wall stiffness (measured via pressure-diameter tests) and histological evaluation of atherosclerotic lesions at 8 weeks.surrogate
In a rabbit model, early progression of atherosclerosis induced by a high-cholesterol diet is associated with a significant decrease in aortic wall stiffness.
Limitations
- Determination of wall stiffness instead of wall elasticity
- Fixed ends of the aortic specimens during mechanical testing constrict the axial deformation that occurs in vivo
Cite This Study
Koniari et al. (2011) studied this question.
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