Why the study?
Does aortic constriction reduce atherogenesis in rabbits on a high cholesterol diet?
Population
Rabbits subjected to bilateral lumbar sympathectomy and fed a high cholesterol diet
Comparison
Aortic constriction vs No aortic constriction
Design
Preclinical
Authors
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Supports hemodynamic modulation of experimental atherogenesis; leaves open translation to human atherosclerosis.
Does aortic constriction reduce atherogenesis in rabbits on a high cholesterol diet?
Aortic constriction in a rabbit model reduces distal atherogenesis, suggesting a role for hemodynamics and blood pressure in atherosclerosis development.
Snyder et al. (1958) studied this question.
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