Why the study?
Does reduction of aortic wall motion prevent intimal plaque formation in a rabbit model of hypertension-mediated atherosclerosis?
Does reduction of aortic wall motion prevent intimal plaque formation in a rabbit model of hypertension-mediated atherosclerosis?
Localized inhibition of aortic wall motion in a hypertensive rabbit model significantly reduces intimal plaque formation, suggesting cyclic motion stimulates atherosclerosis.
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Supports role of cyclic wall motion in hypertension-driven atherosclerosis; leaves open whether targeting motion alters human disease progression.
Tropea et al. (2000) studied this question.