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July 1, 1988Arteriosclerosis An Official Journal of the American Heart Association Inc

Inhibition of atherosclerosis associated with reduction of arterial intramural stress in rabbits.

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Key Points

To determine whether reducing arterial intramural wall stress prevents the development of atherosclerotic lesions at arterial branch points.
Fitted rigid acrylic casts around the left renal artery origin (n=5) or aortic bifurcation (n=5) during pharmacologically lowered arterial pressure (35–45 mm Hg) to prevent arterial expansion at normal pressures.
Evaluated controls including unoperated (n=2), sham-operated (n=2), silicone rubber casted (n=2), and high-pressure casted rabbits (n=4 at 95 mm Hg).
Fed all rabbits a 2% cholesterol-enriched diet for 7 to 11 weeks prior to arterial tissue and lumen dimension examination.
Atherosclerotic lesions completely failed to develop at rigid-casted renal artery origins and aortic bifurcations when casts were applied under low pressure.
Lesions developed normally across other uncasted arterial branches and in control vessels casted at 95 mm Hg pressure.
Aortic lumen diameter and wall thickness measurements confirmed that rigid casts caused no significant lumen narrowing or wall thinning.

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Implication

Experimental study reveals that reducing arterial wall intramural stress prevents atherosclerotic plaque formation in hypercholesterolemic rabbits, indicating mechanical tension drives lesion growth.

Cite This Study

Thubrikar et al. (1988) studied this question.

synapsesocial.com/papers/6a755ea680fadadbba095b7f https://doi.org/10.1161/01.atv.8.4.410

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