Why the study?
Does endothelin alter the sensitivity of arterial baroreceptors in dogs?
Does endothelin alter the sensitivity of arterial baroreceptors in dogs?
High concentrations of endothelin suppress baroreceptor activity at high arterial pressures, suggesting a paracrine mechanism that could interfere with the baroreflex and promote hypertension.
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Animal data preclude practice change; leaves open paracrine endothelin effects on baroreflex in hypertension.
Chapleau et al. (1992) studied this question.
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