November 1, 1988Circulation Research

Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.

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Population

Conscious instrumented dogs

Comparison

Intracoronary infusion of prostaglandin I2 at… vs Intracoronary infusion of PGI2 vehicle

Design

Preclinical

Authors

MPM. J. PanzenbeckBoehringer Ingelheim (United States)WTWen TanAffiliated Hospital of Southwest Medical University MHM. A. HajduUniversity of Missouri–Kansas City

Discussion

Member takes

Implication

Warrants no change in clinical practice; leaves open whether PGI2 modulates baroreflex function in humans.

Structured PICO

Population

Conscious instrumented dogs

Intervention

Intracoronary infusion of prostaglandin I2 (PGI2) at doses of 10, 20, and 50 ng/kg/min into the left circumflex coronary artery

Comparator

Intracoronary infusion of PGI2 vehicle

Outcome

Baroreflex control of heart rate (maximum heart rate, heart rate range, and maximum slope of the mean arterial pressure-heart rate curve)surrogate

Intracoronary infusion of PGI2 in conscious dogs attenuates baroreflex-mediated tachycardia by preventing parasympathetic withdrawal and attenuating sympathetic stimulation.

Cite This Study

Panzenbeck et al. (1988) studied this question.

synapsesocial.com/papers/6a7b7ebf756812e3958a0794 https://doi.org/10.1161/01.res.63.5.860

View Full Paper

Ask AI

Bookmark

Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider