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September 1, 1992Clinical and Experimental Pharmacology and Physiology

Intracoronary Pge2 and Veratrine Inhibits Renin Release in Conscious Dogs via Chemosensitive Ventricular Afferents

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Population

Conscious instrumented dogs

Comparison

Intracoronary artery infusions of veratrine and… vs Intravenous infusions of nitroprusside

Design

Preclinical

Authors

AGAndrew GormanIdaho National LaboratoryJCJ. S. ChenUniversity of Nebraska Medical CenterSFSteven FosterLeeds Community Healthcare NHS Trust

Discussion

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Implication

Supports ventricular afferent modulation in canine hypotension; leaves open translation to human baroreflex and renin control.

Structured PICO

P
Population
Conscious instrumented dogs
I
Intervention
Intracoronary artery infusions of veratrine (0.2-0.8 micrograms/kg per min) and PGE2 (10-50 ng/kg per min)
C
Comparator
Intravenous infusions of nitroprusside (producing a 15-20 mmHg decrease in arterial pressure)
O
Outcome
Plasma renin activity (PRA) and heart ratesurrogate

Intracoronary veratrum alkaloids and prostaglandins inhibit hypotension-induced increases in plasma renin activity and heart rate in conscious dogs via chemosensitive ventricular afferents.

Cite This Study

Gorman et al. (1992) studied this question.

synapsesocial.com/papers/6a85467032b8a2b0ded6a85dhttps://doi.org/10.1111/j.1440-1681.1992.tb00517.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PGE2 and arachidonate inhibit the baroreflex in conscious dogs via cardiac receptors1989 · 28 citations
  2. 2Prostacyclin (PGI2) Elicits Reflex Bradycardia in Dogs: Evidence for Vagal Mediation1979 · 38 citations
  3. 3Attenuation of arterial baroreflex control of heart rate by left ventricular receptor stimulation in the conscious dog.1983 · 28 citations
  4. 4Continuous inhibition of renin release in dogs by vagally innervated receptors in the cardiopulmonary region.1975 · 99 citations
  5. 5Interaction between the baroreceptor and Bezold-Jarisch reflexes1979 · 34 citations