Intracoronary veratrine attenuates carotid baroreceptor reflex regulation of blood pressure in conscious dogs.

Conscious dogs with denervated aortic baroreceptors, equipped with aortic flow probes, cardiac pacing electrodes, and catheters in the aorta, vena cava, and left circumflex coronary artery, with both carotid sinus regions prepared for reversible vascular isolation.

Intracoronary infusion of veratrine (0.1-1.0 micrograms kg-1 min-1) into the left circumflex coronary artery.

Intravenous veratrine or intracoronary infusion of vehicle.

Carotid baroreflex control of blood pressure, heart rate, cardiac output, and total peripheral resistance.surrogate