November 1, 1987Circulation Research
Effects of Left Ventricular Receptor Stimulation on Coronary Blood Flow in Conscious Dogs
Key result
Intracoronary administration of veratridine decreased late diastolic coronary resistance by 34.7±5.0% in awake dogs, a reflex completely accountable by a cholinergic mechanism.
Why the study?
Does intracoronary veratridine decrease coronary resistance in conscious dogs?
Population
10 conscious, chronically instrumented intact and sinoaortic denervated dogs
Comparison
Bolus intracoronary injections of veratridine… vs Baseline/control state before injection
Design
Preclinical
Authors
Discussion
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Implication
Cholinergic reflex coronary vasodilation occurs in awake dogs; extends mechanistic insights but leaves open human relevance.
Structured PICO
Does intracoronary veratridine decrease coronary resistance in conscious dogs?
P
Population
10 conscious, chronically instrumented intact and sinoaortic denervated dogs.
I
Intervention
Bolus intracoronary injections of veratridine (0.1-0.4 µg/kg) administered in the unblocked state, after β-receptor blockade, after α-receptor blockade, and after cholinergic blockade
C
Comparator
Baseline/control state before injection
O
Outcome
Coronary blood flow and resistancesurrogate
Main Result
Effect estimate: -34.7%
Cardiac receptor stimulation by veratridine causes a reflex decrease in coronary resistance in awake dogs that is completely mediated by a cholinergic mechanism.
Cite This Study
Zucker et al. (1987) studied this question. veratridine vs. baseline was evaluated on late diastolic coronary resistance (-34.7%). Intracoronary administration of veratridine decreased late diastolic coronary resistance by 34.7±5.0% in awake dogs, a reflex completely accountable by a cholinergic mechanism.