Key result
Intracoronary infusion of veratrine attenuated arterial baroreflex control of heart rate in conscious dogs, reducing peak sensitivity and heart rate range via parasympathetic pathways.
Why the study?
Does left ventricular receptor stimulation by veratrine attenuate arterial baroreflex control of heart rate in conscious dogs?
Population
Conscious dogs
Comparison
Intracoronary infusion of veratrine into the… vs Baseline (control) before infusion
Design
Preclinical
Authors
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LV receptor stimulation attenuates baroreflex via parasympathetic pathways in dogs; leaves open translation to human autonomic regulation.
Does left ventricular receptor stimulation by veratrine attenuate arterial baroreflex control of heart rate in conscious dogs?
Left ventricular receptor stimulation attenuates arterial baroreflex control of heart rate, with sensitivity reduction mediated by parasympathetic pathways and set point resetting by sympathetic pathways.
Holmberg et al. (1983) studied this question. Intracoronary infusion of veratrine vs. Control (before infusion) was evaluated on Arterial baroreflex control of heart rate (peak sensitivity and heart rate range). Intracoronary infusion of veratrine attenuated arterial baroreflex control of heart rate in conscious dogs, reducing peak sensitivity and heart rate range via parasympathetic pathways.
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