August 1, 1989Journal of Cardiovascular Pharmacology
Prostaglandin E1 and Nitroglycerin Effects on Canine Epicardial Conductance and Distal Coronary Resistance Vessels
Why the study?
Does Prostaglandin E1 improve epicardial conductance and distal coronary resistance compared to nitroglycerin in a canine model?
Population
Closed-chest dog model
Comparison
Prostaglandin E1 infusion into the left anterior… vs Nitroglycerin infusion into the left anterior…
Design
Preclinical
Authors
Discussion
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Implication
Challenges attribution of PGE1 benefits in unstable angina to epicardial dilation; leaves open distal resistance vessel effects for further study.
Structured PICO
Does Prostaglandin E1 improve epicardial conductance and distal coronary resistance compared to nitroglycerin in a canine model?
P
Population
Closed-chest dog model
I
Intervention
Prostaglandin E1 (PGE1) infusion into the left anterior descending (LAD) artery
C
Comparator
Nitroglycerin infusion into the left anterior descending (LAD) artery
O
Outcome
Epicardial coronary and distal resistance vessel responses measured by coronary angiography and 133Xe washout flowsurrogate
PGE1 dilates distal resistance vessels but does not significantly dilate epicardial conductance coronary arteries or reverse endogenous contractile factors, suggesting its benefits in unstable angina are not due to epicardial vasorelaxation.
Cite This Study
Miller et al. (1989) studied this question.