Population
Isolated Langendorff-perfused rat hearts
Design
Preclinical
Authors
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These rat heart findings warrant no clinical change; leaves open prostaglandin interactions for in vivo validation.
Prostaglandins exhibit diverse, concentration-dependent actions on coronary perfusion and myocardial contractility in isolated rat hearts, which are significantly modulated by the presence of other prostaglandins.
Karmazyn et al. (1979) studied this question.
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