What question did this study set out to answer?

January 1, 1970The Tohoku Journal of Experimental MedicineOpen Access

Effects of Prostaglandins E1 and F1α on the Heartlung Preparation of the Dog

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Population

15 mongrel dogs of either sex, weighing between 7.5 and 11 kg, using the heart-lung preparation.

Comparison

Prostaglandin E1 and Prostaglandin F1α injected… vs Nitroglycerine, eledoisin-like polypeptide, and…

Design

Preclinical

Authors

MKMakoto KatoriChuo University KTKeisuke TakedaKyushu University SIShoichi ImaiMie University

Discussion

Member takes

Implication

PGE1 cardiac effects in canine models leave open translation to human heart failure therapy; prospective studies required.

Key Points

To evaluate the cardiac and vascular actions of prostaglandin E1 (PGE1) and prostaglandin F1α (PGF1α) in isolated canine heart-lung preparations.
Assessed cardiac action of PGE1 and PGF1α in an isolated dog heart-lung preparation.
Administered prostaglandins via injection into either the left atrium or the venous-supply tubing to compare circulatory routes.
Measured myocardial contractility, coronary blood flow, heart rate, and oxygen consumption.
Left atrial injection of PGE1 elicited a positive inotropic effect (notably in failing hearts), left heart rate unchanged, and increased coronary blood flow by an average of 21% alongside an average 5% increase in oxygen consumption.
Venous injection required 50 to 80 times the dose of PGE1 to match the coronary flow increase of left atrial injection, indicating 98% to 99% pulmonary clearance in a single passage.
PGF1α demonstrated weak cardiac activity, requiring large doses to elicit effects qualitatively similar to PGE1.

Structured PICO

Population

15 mongrel dogs of either sex, weighing between 7.5 and 11 kg, using the heart-lung preparation.

Intervention

Prostaglandin E1 (PGE1) and Prostaglandin F1α (PGF1α) injected into the left atrium or venous-supply tubing.

Comparator

Nitroglycerine, eledoisin-like polypeptide, and comparison between left atrial versus venous-supply tubing injection routes.

Outcome

Changes in cardiac contractility (inotropic effect), heart rate, coronary flow, and myocardial oxygen consumption.surrogate

PGE1 exerts a direct positive inotropic and coronary vasodilator effect in the isolated dog heart, but is almost entirely cleared by the pulmonary circulation.

Cite This Study

Katori et al. (1970) studied this question.

synapsesocial.com/papers/6a732fa164decaab472c1cb3 https://doi.org/10.1620/tjem.101.67

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Effects of Prostaglandins E1 and F1α on the Heartlung Preparation of the Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Prostaglandins E1 and F1α on the Heartlung Preparation of the Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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