Why the study?
Does direct injection of prostaglandin E1 or F2α into the sinus node artery affect heart rate in dogs?
Does direct injection of prostaglandin E1 or F2α into the sinus node artery affect heart rate in dogs?
This preclinical study aimed to determine whether prostaglandins E1 and F2α exert a direct chronotropic effect on the sinus node when injected locally.
Answers are grounded in this paper and cite their sources.
No clinical implications from this canine model; leaves open direct sinus node chronotropic effects of prostaglandins.
A number of investigators have found that intravenous injection of prostaglandin E1 (PGE1) or prostaglandin F2α(PGF2α) increased heart rate in humans (Bergstrom et al. (1)) and in dogs (Nakano and McCurdy (2); Emerson et al. (3)). Lavery et al. (4) also showed that the intra-vertebral arterial injection of PGE1 and PGF2α also increased heart rate in dogs. Nakano and McCurdy (2) showed that the tachycardia induced by intravenous injection of PGE1 was completely abolished by the administration of propranolol (1 mg/kg). The present study was undertaken to examine whether or not PGE1 or PGF2α has a direct effect on the sinus node by injecting the prostaglandins into an isolated sinus node artery.
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Chiba et al. (1972) studied this question.
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