Why the study?
Does intravenous prostaglandin A1 alter systemic and coronary hemodynamics in conscious dogs?
Population
13 intact, conscious dogs after recovery from operation for implantation of Doppler ultrasonic flow probes…
Comparison
Intravenous prostaglandin A1 in graded doses vs Baseline (control) prior to administration
Design
Preclinical
Authors
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PGA1 shows vasodilatory effects in conscious dogs; leaves open translation to human hemodynamics.
Does intravenous prostaglandin A1 alter systemic and coronary hemodynamics in conscious dogs?
Prostaglandin A1 acts as both a primary and secondary coronary vasodilator, increasing cardiac output and decreasing total systemic resistance in a conscious canine model.
Higgins et al. (1971) studied this question.
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