Key result
Prostaglandins E1, E2, A1, and A2 dilated capacitance vessels significantly more than nitroglycerine, highlighting the importance of capacitance changes to their haemodynamic response.
Prostaglandins E1, E2, A1, and A2 dilate capacitance vessels in the dog hind limb, with the PGA series showing a greater capacitance effect than the PGE series or nitroglycerine.
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Should not change clinical vasodilator selection; leaves open translation of capacitance effects to human haemodynamics.
The responses to four prostaglandins E1, E2, A1 and A2 have been studied after intra-arterial injection into the hind limb of the anaesthetized dog, perfused at constant flow. The regression lines of resistance vessel response to dose gave a potency ratio relative to PGEi of 0.42 for PGE2 and 0.06 for PGA2. The relative potency of PGA2 to PGA1 was 0.36. All compounds dilated capacitance vessels. For a given degree of arterial dilatation the capacitance effect of the PGA series was significantly greater than that of PGE1 or PGE2 and all the prostaglandins produced a greater effect on capacitance vessels than did nitroglycerine. These findings indicate the importance of the capacitance changes to the haemodynamic response produced by the prostaglandins.
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Conway et al. (1975) studied this question. Prostaglandins E1, E2, A1, and A2 vs. Nitroglycerine and PGE1 was evaluated on Resistance vessel response and capacitance vessel dilation (Potency ratio relative to PGE1 of 0.42 for PGE2 and 0.06 for PGA2). Prostaglandins E1, E2, A1, and A2 dilated capacitance vessels significantly more than nitroglycerine, highlighting the importance of capacitance changes to their haemodynamic response.
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