Why the study?
Does thiopental reduce the epinephrine dose required to induce arrhythmias in dogs anesthetized with halothane?
Population
21 dogs (14 in Group 1, 7 in Group 2)
Comparison
Intravenous thiopental combined with halothane… vs Halothane alone with graded doses of epinephrine…
Design
Preclinical
Authors
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May heighten arrhythmia risk with thiopental-halothane-epinephrine in dogs; leaves open translation to human anesthesia.
Does thiopental reduce the epinephrine dose required to induce arrhythmias in dogs anesthetized with halothane?
Thiopental potentiates halothane-epinephrine-induced ventricular arrhythmias by reducing the epinephrine dose threshold required to trigger them in a dog model.
Atlee et al. (1982) studied this question.
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