January 1, 1977The Journal of Toxicological SciencesOpen Access

Electrophysiological Study on the So-Called Sensitizing Effect of Halothane to Catecholamines in the Dog Cardiac Muscle

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Population

Canine cardiac fibers (right bundle branch and sinus node preparations)

Design

Preclinical

Authors

YKYutaka KasuyaTokyo Metropolitan Institute of Gerontology SHShigehiro HayashiTokyo Medical University KSKoki ShigenobuThe University of Tokyo

Discussion

Member takes

Implication

Suggests mechanism for halothane-epinephrine arrhythmias in ventricular fibers; leaves open clinical relevance in anesthesia.

Structured PICO

Population

Canine cardiac fibers (right bundle branch and sinus node preparations)

Intervention

Halothane (1.3% v/v) and epinephrine

Outcome

Pacemaker activity (slope of pacemaker potential and rate of firing)surrogate

Halothane augments the positive chronotropic action of epinephrine in right bundle branch fibers but not atrial preparations, providing an electrophysiological basis for halothane-epinephrine induced arrhythmias.

Cite This Study

Kasuya et al. (1977) studied this question.

synapsesocial.com/papers/6a95d69ab5302ee6c2e6c8c6 https://doi.org/10.2131/jts.2.35

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Electrophysiological Study on the So-Called Sensitizing Effect of Halothane to Catecholamines in the Dog Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological Study on the So-Called Sensitizing Effect of Halothane to Catecholamines in the Dog Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider