April 1, 1982British Journal of Clinical PharmacologyOpen Access

Beta‐adrenoceptor blockade and atrio‐ventricular conduction in dogs. Role of intrinsic sympathomimetic activity.

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Population

Anaesthetized dogs

Design

Preclinical

Authors

GJGiudicelli JfUniversité Paris-Sud FLF LhosteUniversité Paris-Sud

Discussion

Member takes

Implication

ISA may protect AV conduction in canine models; hypothesis-generating and should not yet change clinical beta-blocker selection.

Structured PICO

Population

Anaesthetized dogs

Intervention

Six beta-adrenoceptor blocking agents ((+/-)-propranolol, sotalol, atenolol, pindolol, practolol, (+)-propranolol) and isoprenaline

Outcome

Atrial (AERP), nodal (NERP), global (GERP) effective refractory periods, and global functional refractory period (GFRP)surrogate

In a canine model, beta-adrenoceptor blockade impairs atrio-ventricular conduction, but intrinsic sympathomimetic activity (ISA) affords protection against this impairment.

Cite This Study

Jf et al. (1982) studied this question.

synapsesocial.com/papers/6a840cee880bd6494af7965e https://doi.org/10.1111/j.1365-2125.1982.tb01906.x

View Full Paper

Ask AI

Bookmark

Beta‐adrenoceptor blockade and atrio‐ventricular conduction in dogs. Role of intrinsic sympathomimetic activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Beta‐adrenoceptor blockade and atrio‐ventricular conduction in dogs. Role of intrinsic sympathomimetic activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider