Why the study?
Does beta-adrenoreceptor blockade prolong ventricular refractoriness and action potential duration in closed-chest dogs?
Population
Closed-chest dogs under pentobarbital anesthesia (to increase sympathetic tone)
Design
Preclinical
Authors
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Supports beta-blocker effects on canine ventricular refractoriness independent of selectivity or ISA; leaves open human translation.
Does beta-adrenoreceptor blockade prolong ventricular refractoriness and action potential duration in closed-chest dogs?
Beta-blockers prolong ventricular refractoriness and action potential duration in the presence of adrenergic stimulation, independent of cardioselectivity or intrinsic sympathomimetic activity.
Amlie et al. (1982) studied this question.
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