Why the study?
Does autonomic blockade modify the electrophysiologic response to digitoxin in the right ventricle of dogs?
Population
25 pentobarbital-anaesthetised Labrador dogs
Comparison
Digitoxin intravenously over 5 min with… vs Digitoxin intravenously over 5 min without…
Design
Preclinical
Follow-up
8 hours
Authors
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Autonomic interactions mediate digitoxin's repolarization effects in dogs; leaves open relevance to human therapy.
Does autonomic blockade modify the electrophysiologic response to digitoxin in the right ventricle of dogs?
Autonomic blockade reveals that the direct effect of digitoxin is to shorten action potential duration, indicating that its prolonging effect is mediated by interaction with autonomic transmitters.
Jan Amlie (1980) studied this question.
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