Key result
Pharmacological blockade of autonomic control of the heart diminished cardiac output during moderate (-23%) and severe (-25%) exercise by reducing heart rate and myocardial contractile force.
Why the study?
Does pharmacological blockade of autonomic control alter cardiac output and heart rate in exercising dogs?
Population
Dogs performing mild, moderate, and severe running exercise on a level treadmill
Comparison
Pharmacological blockade of autonomic control of… vs Without drugs
Design
Preclinical
Authors
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Caution against extrapolating canine results to humans; leaves open autonomic contributions to exercise cardiac output in patients.
Does pharmacological blockade of autonomic control alter cardiac output and heart rate in exercising dogs?
Pharmacological autonomic blockade in dogs reduces cardiac output during exercise by decreasing heart rate and myocardial contractile force, without altering resting cardiac output.
Atkins et al. (1977) studied exercising dogs. Pharmacological blockade of autonomic control (atropine and propranolol) vs. without drugs was evaluated on cardiac output. Pharmacological blockade of autonomic control of the heart diminished cardiac output during moderate (-23%) and severe (-25%) exercise by reducing heart rate and myocardial contractile force.
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