What question did this study set out to answer?

To elucidate the distinct roles of the sympathetic and parasympathetic nervous systems in mediating cardiovascular responses during voluntary static exercise.

October 1, 1980Circulation ResearchOpen Access

Cardiovascular response to static exercise during selective autonomic blockade in the conscious cat.

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Why the study?

Does selective autonomic blockade alter cardiovascular responses during static exercise in conscious cats?

Population

7 conscious cats operantly conditioned to hold a bar against a fixed resistance for 15 seconds

Comparison

Selective autonomic blockade with propranolol… vs Unblocked state during static exercise

Design

Preclinical

Authors

GDG. R. DiepstraThe University of Texas Southwestern Medical Center WGW. J. GonyeaThe University of Texas Southwestern Medical Center JMJ. H. MitchellTexas Health Harris Methodist Hospital Fort Worth

Discussion

Member takes

Implication

Should not change clinical practice; hypothesis-generating for autonomic mediation of exercise hemodynamics in humans.

Key Points

To elucidate the distinct roles of the sympathetic and parasympathetic nervous systems in mediating cardiovascular responses during voluntary static exercise.
Operantly conditioned seven conscious cats (N=7) to hold a bar against fixed resistances of 100 g and 200 g for 15 seconds during progressive exercise training.
Administered selective pharmacologic autonomic blockade using propranolol (beta-adrenergic blockade), atropine (muscarinic blockade), and combined atropine and propranolol during static exercise sessions.
Baseline static exercise at 200 g resistance increased heart rate by 10%, left ventricular systolic pressure by 16%, and left ventricular max dp/dt by 18%.
Propranolol abolished the exercise-induced increase in left ventricular max dp/dt, whereas atropine abolished the early increase in heart rate.
Combined blockade suppressed both heart rate and left ventricular max dp/dt increases while left ventricular systolic pressure elevations persisted.

Structured PICO

Does selective autonomic blockade alter cardiovascular responses during static exercise in conscious cats?

Population

7 conscious cats operantly conditioned to hold a bar against a fixed resistance for 15 seconds

Intervention

Selective autonomic blockade with propranolol, atropine, and combined atropine and propranolol

Comparator

Unblocked state during static exercise

Outcome

Cardiovascular responses (heart rate, left ventricle systolic pressure, and LV max dp/dt) during voluntary static exercisesurrogate

This preclinical study demonstrates that during static exercise, heart rate increases are primarily mediated by the parasympathetic nervous system, while increases in LV contractility (max dp/dt) are mediated by the sympathetic nervous system.

Cite This Study

Diepstra et al. (1980) studied this question.

synapsesocial.com/papers/6a76915c232067cbf2ec1cea https://doi.org/10.1161/01.res.47.4.530

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Cardiovascular response to static exercise during selective autonomic blockade in the conscious cat.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiovascular response to static exercise during selective autonomic blockade in the conscious cat.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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