Why the study?
Does autonomic blockade alter cardiovascular responses to exercise in rats?
Population
Sprague-Dawley rats (n = 10) instrumented with arterial and venous catheters and Doppler flow probes
Comparison
Atropine methyl nitrate, timolol maleate, and… vs Saline (1 mg/kg iv)
Design
Preclinical
Authors
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Supports SNS mediation of exercise hemodynamics in rats; leaves open translation to human physiology and practice.
Does autonomic blockade alter cardiovascular responses to exercise in rats?
The sympathetic nervous system is a key mediator of exercise-induced tachycardia and hyperemia in rats, both of which are attenuated by nonselective beta-blockade.
J. M. Overton (1993) studied this question.
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