October 1, 2002Annals of Noninvasive ElectrocardiologyOpen Access

Cardiovascular Autonomic Function in Conscious Rats: A Novel Approach to Facilitate Stationary Conditions

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Population

Conscious rats

Comparison

Pharmacological autonomic blockade using a… vs Baseline conditions

Design

Preclinical

Authors

DRDirk RamaekersKU Leuven FBFrank BeckersWitten/Herdecke University HDHilde DemeulemeesterUniversitair Ziekenhuis Leuven

Discussion

Member takes

Implication

Establishes vagal dominance in rodent baroreflex; leaves open translation to human autonomic assessment.

Structured PICO

Population

Conscious rats

Intervention

Pharmacological autonomic blockade (propranolol, phentolamine, atropine) using a restrained approach

Comparator

Baseline conditions

Outcome

Time- and frequency-domain indices of heart rate variability (HRV), blood pressure variability (BPV), and spontaneous baroreflex sensitivity (spBRS)surrogate

The study validates a novel restrained approach for evaluating cardiovascular autonomic function in conscious rats, demonstrating that the baroreflex depends mainly on changes in vagal activity.

Cite This Study

Ramaekers et al. (2002) studied this question.

synapsesocial.com/papers/6a8bf630f8241cb45bfb7810 https://doi.org/10.1111/j.1542-474x.2002.tb00179.x

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Cardiovascular Autonomic Function in Conscious Rats: A Novel Approach to Facilitate Stationary Conditions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiovascular Autonomic Function in Conscious Rats: A Novel Approach to Facilitate Stationary Conditions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider