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November 1, 1995AJP Heart and Circulatory Physiology

Atropine significantly reduced HF R-R interval power (from 1.73 +/- 0.50 to 0.39 +/- 0.27 ms2, P < 0.01) and virtually abolished MF R-R interval power (from 0.48 +/- 0.44 to 0.01 +/- 0.01 ms2, P < 0.01), whereas propranolol did not significantly affect these parameters.

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Population

13 freely behaving WKY rats instrumented with venous and arterial catheters and chest electrodes

Comparison

Intravenous atropine and/or propranolol vs Control condition (baseline)

Design

Preclinical

Follow-up

90 min

Authors

SPStefano PerliniFGF. GiangregorioMCM. Coco

Discussion

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Overview

Parasympathetic mediation of rat HF/MF HRV is supported; leaves open translation to human autonomic assessment.

Structured PICO

P
Population
13 freely behaving WKY rats instrumented with venous and arterial catheters and chest electrodes
I
Intervention
Intravenous atropine (0.75 mg/kg) and/or propranolol (1 mg/kg)
C
Comparator
Control condition (baseline)
O
Outcome
Spectral power in the 0.25- to 0.75-Hz (midfrequency, MF) and the 0.75- to 3.0-Hz (high-frequency, HF) bands of R-R interval and mean arterial pressure (MAP)surrogate

In freely behaving rats, parasympathetic blockade with atropine significantly reduces both high-frequency and mid-frequency heart rate and blood pressure variability, whereas sympathetic blockade with propranolol has no significant effect.

Cite This Study

Perlini et al. (1995) studied this question.

synapsesocial.com/papers/6a8bea28dd62e0468bc5d3afhttps://doi.org/10.1152/ajpheart.1995.269.5.h1729
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