Why the study?
Does pharmacological autonomic blockade alter heart rate and blood pressure variability in unanesthetized rats?
Population
Chronically instrumented, unanesthetized, freely moving rats
Comparison
Beta-adrenergic receptor blockade, cholinergic… vs Control condition (no pharmacological blockade)
Design
Preclinical
Follow-up
90 minutes per condition
Authors
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Highlights vagal buffering of BP variability in rat models; leaves open translation to human autonomic therapies.
Does pharmacological autonomic blockade alter heart rate and blood pressure variability in unanesthetized rats?
Vagal, but not sympathetic, influences on heart rate variability play an antioscillatory role in buffering blood pressure variability in rats.
Ferrari et al. (1987) studied this question.
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