Key result
S-16257 decreased heart rate by 29% and markedly increased heart rate variability, demonstrating a negative correlation dependent on the autonomic nervous system.
Population
Normal adult conscious rats (n=10)
Comparison
S-16257 alone or in combination with atropine… vs Placebo (crossover design)
Design
Preclinical
Authors
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Hypothesis-generating in animals; leaves open whether autonomic dependence of the HR-HRV relationship translates to human therapy.
RCT (n=10)
The inverse relationship between heart rate and heart rate variability is dependent on autonomic nervous system modulation rather than intrinsic pacemaker properties.
Mangin et al. (1998) conducted an RCT in Normal adult conscious rats (n=10). S-16257 vs. Placebo was evaluated on Heart rate and heart rate variability. S-16257 decreased heart rate by 29% and markedly increased heart rate variability, demonstrating a negative correlation dependent on the autonomic nervous system.
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