Why the study?
Does atropine methylnitrate affect time and frequency domain estimates of blood pressure and heart rate variability in conscious mice?
Population
8 conscious mice equipped with a blood pressure telemetric device, evaluated at rest
Comparison
Atropine methylnitrate injection (2 mg/kg) vs Control period
Design
Preclinical
Authors
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Should not inform clinical HRV assessment; leaves open validation of pNN8 and LF gain in translational models.
Does atropine methylnitrate affect time and frequency domain estimates of blood pressure and heart rate variability in conscious mice?
In a preclinical mouse model, atropine significantly alters heart rate variability indices, demonstrating resting vagal predominance and identifying pNN8 and LF gain as optimal markers of vagal tone.
Laude et al. (2008) studied this question.
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