January 1, 2000AJP Regulatory Integrative and Comparative Physiology

Short-term and long-term blood pressure and heart rate variability in the mouse

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Population

Swiss mice (n=9)

Comparison

Intravenous injection of autonomic blockers and… vs Resting (control) state

Design

Preclinical

Follow-up

up to 3 wk

Authors

BJBen JanssenMaastricht University Medical Centre PLPeter LeendersMaastricht University JSJos F.M. SmitsMACOM (United States)

Discussion

Member takes

Implication

Murine sympathetic BP control findings warrant no clinical change; leaves open translation to human autonomic regulation.

Structured PICO

Population

Swiss mice (n=9)

Intervention

Intravenous injection of autonomic blockers (hexamethonium, prazosin, metoprolol, atropine) and N(G)-nitro-L-arginine methyl ester

Comparator

Resting (control) state

Outcome

Mean arterial pressure (MAP) and pulse interval (PI) variabilitysurrogate

This study demonstrates that murine blood pressure variability is primarily sympathetically mediated, while pulse interval variability is controlled by both vagal and sympathetic nerves, with nitric oxide buffering blood pressure fluctuations.

Cite This Study

Janssen et al. (2000) studied this question.

synapsesocial.com/papers/6a7150baac440176ef29fdd0 https://doi.org/10.1152/ajpregu.2000.278.1.r215

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Short-term and long-term blood pressure and heart rate variability in the mouse

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Short-term and long-term blood pressure and heart rate variability in the mouse

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider