Key result
The spontaneous and sequence methods for assessing baroreflex function did not provide reliable or valid data comparable to the traditional pharmacological method in resting rats.
Population
Resting, normotensive Sprague-Dawley rats
Comparison
Spontaneous method and sequence method vs Traditional method assessing heart rate changes…
Design
Preclinical
Authors
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Spontaneous/sequence baroreflex methods unreliable vs pharmacological in resting rats; leaves open validation in disease models or other species.
Spontaneous and sequence methods for assessing baroreflex function are not reliable or valid alternatives to the traditional pharmacological method in resting, normotensive rats under the studied conditions.
Moffitt et al. (2005) studied Normotensive. Spontaneous and sequence methods vs. Traditional Oxford method (pharmacological method) was evaluated on Reliability and validity of correlating spontaneous changes in systolic blood pressure and heart rate. The spontaneous and sequence methods for assessing baroreflex function did not provide reliable or valid data comparable to the traditional pharmacological method in resting rats.
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