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February 1, 1995AJP Regulatory Integrative and Comparative Physiology

Assessment of spontaneous baroreflex sensitivity in rats a new method using the concept of statistical dependence

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Population

32 conscious rats

Comparison

Evaluation of spontaneous baroreflex sensitivity… vs Pharmacological baroreflex sensitivity estimated…

Design

Preclinical

Authors

CCCatherine CeruttiUniversité Claude Bernard Lyon 1MDMichel DucherUniversité Claude Bernard Lyon 1PLPierre LantelmeUniversité Claude Bernard Lyon 1

Discussion

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Implication

Supports spontaneous BRS estimation in rat models; leaves open clinical translation pending human validation.

Structured PICO

P
Population
32 conscious rats (13 control, 12 with pharmacologically induced hypertension, 7 with chronic sinoaortic denervation)
I
Intervention
Evaluation of spontaneous baroreflex sensitivity (Sp-BRS) using a new method based on statistical dependence between mean arterial pressure and heart rate
C
Comparator
Pharmacological baroreflex sensitivity (Ph-BRS) estimated using graded bolus intravenous doses of vasoactive drugs
O
Outcome
Correlation between spontaneous BRS (Sp-BRS) and pharmacological BRS (Ph-BRS)surrogate

A new method based on statistical dependence accurately estimates cardiac baroreflex sensitivity from spontaneous blood pressure and heart rate variations in rats.

Cite This Study

Cerutti et al. (1995) studied this question.

synapsesocial.com/papers/6a7df6036ef7ec97ba7d9378https://doi.org/10.1152/ajpregu.1995.268.2.r382

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of spontaneous baroreflex sensitivity in conscious dogs.1993 · 28 citations
  2. 2Validation of a continuous baroreceptor reflex sensitivity index calculated from spontaneous fluctuations of blood pressure and pulse interval in rats1997 · 103 citations
  3. 3Baroreceptor reflex control of heart rate in rats studied by induced and autogenic changes in arterial pressure2005 · 17 citations
  4. 4NON‐INVASIVE ASSESSMENT OF BAROREFLEX SENSITIVITY AND RELATION TO MEASURES OF HEART RATE VARIABILITY IN MAN1996 · 22 citations
  5. 5The variability of baroreflex sensitivity in juvenile, spontaneously hypertensive rats2011 · 8 citations