Population
19 eight-week-old male spontaneously hypertensive rats (SHRs)
Comparison
Manipulation of mean arterial pressure with… vs Comparison among SHRs divided into four groups…
Design
Preclinical
Authors
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Significant variability in baroreflex sensitivity among SHRs cautions against assuming uniform responses in preclinical models; leaves open standardization needs for hypertension research.
There is significant variability in baroreflex sensitivity among spontaneously hypertensive rats from the same laboratory, suggesting caution when using them as a research model.
Valenti et al. (2011) studied this question.
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