What question did this study set out to answer?

To compare baroreflex control of heart rate between normotensive Wistar-Kyoto and stroke-prone spontaneously hypertensive rats at 1 and 7 months of age.

January 1, 1989Journal of Hypertension

Limited baroreflex control of heart rate in young stroke-prone spontaneously hypertensive rats

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Population

Normotensive and stroke-prone spontaneously hypertensive rats at 1 and at 7 months of age

Comparison

Intravenous phenylephrine and nitroprusside vs Normotensive Wistar-Kyoto (WKY) rats

Design

Preclinical

Authors

PHPeter R.C. HoweUniversity of Southern Queensland PRPaul F. RogersCommonwealth Scientific and Industrial Research Organisation GHGeoffrey A. HeadPreventive Cardiology

Discussion

Member takes

Implication

Baroreflex changes in SHRSP models warrant no clinical extrapolation; leaves open human mechanistic relevance.

Key Points

To compare baroreflex control of heart rate between normotensive Wistar-Kyoto and stroke-prone spontaneously hypertensive rats at 1 and 7 months of age.
Monitored mean arterial pressure and heart rate responses to intravenous phenylephrine and sodium nitroprusside in conscious and anesthetized WKY and SHRSP rats at 1 and 7 months of age.
Characterized baroreflex parameters and gain using linear regression alongside sigmoidal curve-fitting to establish operational limits relative to resting blood pressure.
Baroreflex curves reset to operate at significantly higher resting mean arterial pressure in adult SHRSP compared with normotensive controls.
The total range of heart rate control was smaller in both young (1-month-old) and adult (7-month-old) SHRSP relative to WKY rats, though average gain was not significantly reduced in adult SHRSP.
General anesthesia substantially reduced both the overall heart rate range and average baroreflex gain across both rat strains.

Structured PICO

Population

Normotensive (Wistar-Kyoto, WKY) and stroke-prone spontaneously hypertensive (SHRSP) rats at 1 and at 7 months of age

Intervention

Intravenous phenylephrine and nitroprusside (to assess baroreflex function)

Comparator

Normotensive Wistar-Kyoto (WKY) rats

Outcome

Baroreflex control of heart rate (peak responses of mean arterial pressure and heart rate, baroreflex gain, range of heart rate control)surrogate

Stroke-prone spontaneously hypertensive rats exhibit a reduced range of baroreflex heart rate control and resetting to higher arterial pressures compared to normotensive controls.

Cite This Study

Howe et al. (1989) studied this question.

synapsesocial.com/papers/6a8382316524aee222604e13 https://doi.org/10.1097/00004872-198901000-00011

Topics

Hypertension management

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Limited baroreflex control of heart rate in young stroke-prone spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Limited baroreflex control of heart rate in young stroke-prone spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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