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April 1, 1988Clinical and Experimental Pharmacology and Physiology

Time Course of Changes in Baroreceptor Reflex Control of Heart Rate in Conscious SHR and Wky: Contribution of the Cardiac Vagus and Sympathetic Nerves

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Population

Conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) at 6, 9, 14 and 20 weeks of age

Comparison

Methoxamine- and nitroprusside-induced… vs WKY vs SHR across different ages

Design

Preclinical

Authors

GHGeoffrey A. HeadMAMichael A. Adams

Discussion

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Overview

Hypertension may accelerate age-related vagal baroreflex loss in rats; human studies needed to confirm relevance.

Structured PICO

P
Population
Conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) at 6, 9, 14 and 20 weeks of age
I
Intervention
Methoxamine- and nitroprusside-induced steady-state changes in blood pressure, with and without methylatropine
C
Comparator
WKY vs SHR across different ages
O
Outcome
Baroreflex parameters (HR range and gain) representing the relationship between mean arterial pressure (MAP) and heart rate (HR)surrogate

In a rat model, older spontaneously hypertensive rats show a specific deficit in vagal, but not sympathetic, capacity to control heart rate in response to blood pressure changes.

Cite This Study

Head et al. (1988) studied this question.

synapsesocial.com/papers/6a8383c16f3d9cc948b3fffahttps://doi.org/10.1111/j.1440-1681.1988.tb01075.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reflex Control of Sympathetic Nerve Activity and Heart Rate from Arterial Baroreceptors in Conscious Spontaneously Hypertensive Rats1981 · 61 citations
  2. 2Baroreflex Sensitivity during the Development of Spontaneous Hypertension in Rats1982 · 91 citations
  3. 3Blood pressure and baroreflex sensitivity in conscious hypertensive rats of Lyon strain1986 · 71 citations
  4. 4'Steady-state' properties of the baroreceptor-heart rate reflex in essential hypertension in man1974 · 213 citations
  5. 5Baroreflex Sensitivity Changes during the Development of Goldblatt Two-Kidney One-Clip Hypertension in Rats1980 · 43 citations