Population
Conscious spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats
Comparison
Phenylephrine, nitroprusside, and intravenous… vs Age-matched Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
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Suggests vagal baroreflex impairment in hypertensive models; hypothesis-generating and requires human confirmation before clinical consideration.
This study demonstrates impaired Bezold-Jarisch responses and vagally mediated arterial baroreceptor activity in conscious spontaneously hypertensive rats.
Widdop et al. (1990) studied this question.
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