Key result
Spontaneously hypertensive rats showed greater splanchnic nerve activity but lesser heart rate responses to blood pressure changes compared to normotensive controls.
Why the study?
Does baroreceptor activation elicit different heart rate and sympathetic nerve responses in spontaneously hypertensive rats compared to normotensive controls?
Population
Conscious, stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto controls (WKY)
Comparison
Incremental bolus injections of nitroprusside… vs Normotensive Wistar-Kyoto controls (WKY)
Design
Preclinical
Authors
Loading...
Suggests baroreflex impairment in hypertensive rat models; leaves open human translation and clinical relevance.
Does baroreceptor activation elicit different heart rate and sympathetic nerve responses in spontaneously hypertensive rats compared to normotensive controls?
The discordance in heart rate and splanchnic nerve activity changes in response to baroreceptor activation suggests impaired integration of autonomic function in stroke-prone spontaneously hypertensive rats.
Unger et al. (1987) studied Hypertension. Stroke-prone spontaneously hypertensive rats (SHRSP) vs. Normotensive Wistar-Kyoto controls (WKY) was evaluated on Change in heart rate (HR) and splanchnic nerve activity (SpNA) per change in mean blood pressure (MAP). Spontaneously hypertensive rats showed greater splanchnic nerve activity but lesser heart rate responses to blood pressure changes compared to normotensive controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: